Coumarin: Chemical and Pharmacological Profile
نویسندگان
چکیده
Coumarins are classified as a member of the benzopyrone family. all of which consist of a benzene ring joined to a pyrone ring. The benzopyrones can be subdivided into the benzoalfa-pyrones to which the coumarins belong and the benzo-gama-pyrones, of which the flavonoids are principal members. Umbelliferone, esculetin and scopoletin are the most widespread coumarins in nature. During the synthesis of these compounds ortho-hydroxylation should respectively take place on p-coumaric, caffeic and ferulic acid. The coumarins are of great interest due to their pharmacological properties. In particular, their physiological, bacteriostatic and anti-tumor activity makes these compounds attractive backbone derivatisation and screening as novel therapeutic agents.
منابع مشابه
Molecular Docking and Pharmacological Investigations of Rivastigmine-Fluoxetine and Coumarin–Tacrine hybrids against Acetyl Choline Esterase
UNLABELLED The present AChE inhibitors have been successful in the treatment of Alzheimer׳s Diseases however suffers serious side effects. Therefore in this view, the present study was sought to identify compounds with appreciable pharmacological profile targeting AChE. Analogue of Rivastigmine and Fluoxetine hybrid synthesized by Toda et al, 2003 (dataset1), and Coumarin-Tacrine hybrids synthe...
متن کاملComprehensive review on coumarins: Molecules of potential chemical and pharmacological interest
Coumarins are one of the most important classes of heterocycles that occupies prime position in synthetic and pharmaceutical chemistry due to their diverse applications. Broad spectrum of biological activity and their utility as useful synthons, coumarins have attracted researchers to work on this moiety, which is instrumental in the development of coumarin chemistry. This review article provid...
متن کاملPredictive Modeling of Antioxidant Coumarin Derivatives Using Multiple Approaches: Descriptor-Based QSAR, 3D-Pharmacophore Mapping, and HQSAR
The inability of the systemic antioxidants to alleviate the exacerbation of free radical formation from metabolic outputs and environmental pollutants claims an urgent demand for the identification and design of new chemical entities with potent antioxidant activity. In the present work, different QSAR approaches have been utilized for identifying the essential structural attributes imparting a...
متن کاملConvergence of Free Energy Profile of Coumarin in Lipid Bilayer
Atomistic molecular dynamics (MD) simulations of druglike molecules embedded in lipid bilayers are of considerable interest as models for drug penetration and positioning in biological membranes. Here we analyze partitioning of coumarin in dioleoylphosphatidylcholine (DOPC) bilayer, based on both multiple, unbiased 3 μs MD simulations (total length) and free energy profiles along the bilayer no...
متن کاملCoumarin: A Plant derived Polyphenol with wide Biomedical Applications
In recent years, researchers hunt for a novel anticancer agent mainly from plants. Phytochemicals and ubiquitous bioactive compound plays an important role in drug development. Among various phytochemicals, polyphenols have attracted considerable interest in the past few years due to their potential health benefits. One such phytochemical namely Coumarin (1,2-benzopyrone), a phenolic compound d...
متن کامل